I'm staying at the Rio next time I go to Vegas (which is really soon!). I plan to rent a car. Rio is right next to the freeway, so I can get to the good games downtown in minutes, compared to almost an hour when I take the deuce on the strip. That time savings will pay for itself in EV. I plan to also visit the casinos in the suburbs.
Assuming $150 for a rental for a 4 day trip, you save $30 on the airport cab fare and $28 on the bus pass, both of which you have to pay anyway. You can make up $92 of EV pretty easily with the time you save traveling within Vegas.
Last time I went to Vegas I barely got any sleep. I actually slept on the Deuce bus on my way back to the Flamingo after playing all night downtown. I slept only a few hours till the evening, when I woke up to play poker with the fish, then headed back downtown on the Deuce to play blackjack mostly heads up.